Author: Suzuki, Yoshiyuki
Title: Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation Cord-id: xed3w47t Document date: 2017_5_17
ID: xed3w47t
Snippet: Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality may be useful in screening for susceptibility. In this study, docking simulation was conducted for measles virus hemagglutinin (MVâ€H) and immunoglobulinâ€like variable domain of signaling lymphocyte activation molecule (SLAMâ€V). It was observed that the docking scores for MVâ€H and SLAMâ€V correlated with the activity of SLAM as an MV recept
Document: Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality may be useful in screening for susceptibility. In this study, docking simulation was conducted for measles virus hemagglutinin (MVâ€H) and immunoglobulinâ€like variable domain of signaling lymphocyte activation molecule (SLAMâ€V). It was observed that the docking scores for MVâ€H and SLAMâ€V correlated with the activity of SLAM as an MV receptor. These results suggest that the receptor functionality may be predicted from the docking scores of virion surface proteins and cellular receptor molecules.
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