Author: Cody S. Nelson; Tori Huffman; Eduardo Cisneros de la Rosa; Guanhua Xie; Nathan Vandergrift; Robert F. Pass; Justin Pollara; Sallie R. Permar
Title: HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions Document date: 2018_1_11
ID: bxqc9a7f_29
Snippet: Lastly, we sought to investigate the relationship between measured antibody responses by 239 creating a correlation matrix (Fig. 6) . We observed two distinct clusters of responses that 240 appeared related to one another. The first cluster is comprised of gB-specific phagocytosis 241 activity (of both gB protein and whole HCMV virions), binding responses against free gB protein 242 and membrane-associated gB, and gB-specific IgG1 and IgG3 subcla.....
Document: Lastly, we sought to investigate the relationship between measured antibody responses by 239 creating a correlation matrix (Fig. 6) . We observed two distinct clusters of responses that 240 appeared related to one another. The first cluster is comprised of gB-specific phagocytosis 241 activity (of both gB protein and whole HCMV virions), binding responses against free gB protein 242 and membrane-associated gB, and gB-specific IgG1 and IgG3 subclass responses.
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