Selected article for: "cleavage site and cov virus"
Author: Zhe Liu; Huanying Zheng; Runyu Yuan; Mingyue Li; Huifang Lin; Jingju Peng; Qianlin Xiong; Jiufeng Sun; Baisheng Li; Jie Wu; Ruben J.G. Hulswit; Thomas A. Bowden; Andrew Rambaut; Nick Loman; Oliver G Pybus; Changwen Ke; Jing Lu
Title: Identification of a common deletion in the spike protein of SARS-CoV-2
  • Document date: 2020_4_2
    • ID: 5oisrm5s_4
    Snippet: With respect to the first feature, the similar RBD identified in a SARs-like virus from a pangolin suggests that the RBD in SARS-CoV-2 may already exist in its potential animal host(s) before it transmitted into human 5 . The question remaining is the history and function of the insertion at the S1/S2 boundary, which is uniquely identified in SARS-CoV-2. The insertion of proline is predicted to result in three addition of O-linked glycans. The fu.....
    Document: With respect to the first feature, the similar RBD identified in a SARs-like virus from a pangolin suggests that the RBD in SARS-CoV-2 may already exist in its potential animal host(s) before it transmitted into human 5 . The question remaining is the history and function of the insertion at the S1/S2 boundary, which is uniquely identified in SARS-CoV-2. The insertion of proline is predicted to result in three addition of O-linked glycans. The functional consequence of the polybasic cleavage site and O-linked glycans in SARS-CoV-2 is unknown. By sequencing the whole genome of SARS-CoV-2, we identified two variants having deletion mutations on polybasic cleavage site (PRRAR) and its flank sites. More extensive screening indicates the deletion at the flank sites of PRRAR have been frequently observed in cell isolated strains and could be verified by multiple sequencing methods.

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