Author: Jun Wu; Dingyun Song; Zhongwen Li; Baojie Guo; Yani Xiao; Wenjing Liu; Lingmin Liang; Chunjing Feng; Tingting Gao; Zai Wang; Jianyan Wen; Shengnan Yang; Peipei Liu; Lei Wang; Yukai Wang; Liang Peng; Guihai Feng; Shiqiang Huang; Glyn Nigel Stacey; Wei Li; Yan Huo; Ronghua Jin; Qi Zhou; Liu Wang; Baoyang Hu; Huaping Dai; Jie Hao
Title: Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis Document date: 2020_4_16
ID: 8dpla6jt_75
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.15.042119 doi: bioRxiv preprint 20 dependent manner (Fig. S6) . The expression levels of COL I, FN and α-SMA were also significant lower 512 after IMRC treatment (Fig. S6) . ELISA showed that IMRC treatment reduced both TNF-α and TGF-β1 513 levels in the BLM lung in a dose-dependent manner (Fig. 6H, I) . These results suggested that IM.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.15.042119 doi: bioRxiv preprint 20 dependent manner (Fig. S6) . The expression levels of COL I, FN and α-SMA were also significant lower 512 after IMRC treatment (Fig. S6) . ELISA showed that IMRC treatment reduced both TNF-α and TGF-β1 513 levels in the BLM lung in a dose-dependent manner (Fig. 6H, I) . These results suggested that IMRCs 514 can significantly reduce inflammation and fibrosis after lung injury, in a dose-dependent manner. 515
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