Author: Lee, Nelson; Chan, P.K.S.; Ip, Margaret; Wong, Eric; Ho, Jenny; Ho, Catherine; Cockram, C.S.; Hui, David S.
Title: Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome Cord-id: cnud9p4f Document date: 2005_8_19
ID: cnud9p4f
Snippet: BACKGROUND: The association between a robust or depressed antibody response and clinical severity of SARS remains unknown. OBJECTIVES: To study seroconversion and the magnitude of IgG responses in a SARS cohort with different disease severities. STUDY DESIGN AND METHOD: A retrospective analysis of all acute and convalescent-phase sera collected from a cohort of laboratory-confirmed SARS cases. Anti-SARS-CoV IgG antibody was detected using indirect immunofluorescence technique and quantified by t
Document: BACKGROUND: The association between a robust or depressed antibody response and clinical severity of SARS remains unknown. OBJECTIVES: To study seroconversion and the magnitude of IgG responses in a SARS cohort with different disease severities. STUDY DESIGN AND METHOD: A retrospective analysis of all acute and convalescent-phase sera collected from a cohort of laboratory-confirmed SARS cases. Anti-SARS-CoV IgG antibody was detected using indirect immunofluorescence technique and quantified by two-fold serial dilutions. Characteristics of patients who seroconverted “early†(
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