Selected article for: "cell fusion and target cell"
Author: William E. Diehl; Mehmet H. Guney; Pyae Phyo Kyawe; Judith M. White; Massimo Pizzato; Jeremy Luban
Title: Influence of different glycoproteins and of the virion core on SERINC5 antiviral activity
  • Document date: 2019_9_24
    • ID: 9dybtdi2_6
    Snippet: The block is manifest after virion attachment to target cells, apparently at the stage of fusion pore expansion; virion contents mix with target cell cytoplasm but virion core transfer to the cytoplasm is inhibited (17, 19) . Otherwise isogenic virions pseudotyped with HIV-1 Env glycoproteins from different HIV-1 isolates exhibit a range of dependency on Nef and of sensitivity to SERINC5 (25, 26). SERINC5 increases HIV-1 sensitivity to antibodies.....
    Document: The block is manifest after virion attachment to target cells, apparently at the stage of fusion pore expansion; virion contents mix with target cell cytoplasm but virion core transfer to the cytoplasm is inhibited (17, 19) . Otherwise isogenic virions pseudotyped with HIV-1 Env glycoproteins from different HIV-1 isolates exhibit a range of dependency on Nef and of sensitivity to SERINC5 (25, 26). SERINC5 increases HIV-1 sensitivity to antibodies and peptides targeting the membrane-proximal external region of gp41, suggesting that it somehow alters the conformation of the HIV-1 glycoprotein near the virion membrane (19, 25) .

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