Author: Esposito, Giuseppe; Pesce, Marcella; Seguella, Luisa; Sanseverino, Walter; Lu, Jie; Corpetti, Chiara; Sarnelli, Giovanni
Title: The potential of cannabidiol in the COVIDâ€19 pandemic: a hypothesis letter Cord-id: orw69y3q Document date: 2020_6_10
ID: orw69y3q
Snippet: Identifying candidate drugs effective in the new coronavirus disease 2019 (Covidâ€19) is crucial, pending a vaccine against SARSâ€CoV2. We suggest the hypothesis that Cannabidiol (CBD), a nonâ€psychotropic phytocannabinoid, has the potential to limit the severity and progression of the disease for several reasons: 1) Highâ€CBD Cannabis Sativa extracts are able to downregulate the expression of the two key receptors for SARSâ€CoV2 in several models of human epithelia 2) CBD exerts a wide ran
Document: Identifying candidate drugs effective in the new coronavirus disease 2019 (Covidâ€19) is crucial, pending a vaccine against SARSâ€CoV2. We suggest the hypothesis that Cannabidiol (CBD), a nonâ€psychotropic phytocannabinoid, has the potential to limit the severity and progression of the disease for several reasons: 1) Highâ€CBD Cannabis Sativa extracts are able to downregulate the expression of the two key receptors for SARSâ€CoV2 in several models of human epithelia 2) CBD exerts a wide range of immunomodulatory and antiâ€inflammatory effects and it can mitigate the uncontrolled cytokine production featuring Acute Lung Injury 3) Being a PPARγ agonist, it can display a direct antiviral activity 4) PPARγ agonists are regulators of fibroblast/myofibroblast activation and can inhibit the development of pulmonary fibrosis, thus ameliorating lung function in recovered patients. We hope our hypothesis, corroborated by several preclinical evidence, will inspire further targeted studies to test CBD as a support drug against the COVIDâ€19 pandemic.
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