Distinct early IgA profile may determine severity of COVID-19 symptoms: an immunological case series

Christine Dahlke; Jasmin Heidepriem; Robin Kobbe; Rene Santer; Till Koch; Anahita Fathi; My L. Ly; Stefan Schmiedel; Peter H. Seeberger; Marylyn M. Addo; Felix F. Loeffler

Because of an increase of C-reactive protein (53 mg/dl), oral treatment with a betalactamase antibiotic was started. The patient was hospitalized for four days, and showed moderate but typical ground glass opacities on high-resolution thorax computed tomography scan; he fully recovered without ventilation support. Even though the patient did not require intensive care treatment or ventilation and the symptoms were moderate/severe, we define this patient as a (more) severe case than our other patients, due to hospitalization. Patient #2, his wife, a 62-year-old female, was tested SARS-CoV-2 positive six days after her husband's first symptoms. She had high viral shedding of SARS-CoV-2 monitored by RT-PCR, although she reported only very mild clinical symptoms of COVID-19, such as subfebrile temperatures, a mild cough, and a constant sense of well-being (Pfefferle et al.;