Author: Ishiyama, Aki; Hokari, Rei; Nonaka, Kenichi; Chiba, Takuya; Miura, Hiromi; Otoguro, Kazuhiko; Iwatsuki, Masato
Title: Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial Cord-id: fsmiw3o4 Document date: 2021_1_14
ID: fsmiw3o4
Snippet: A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with ca. 50% inhibition at 30 mg/kg (p.o.).
Document: A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC(50) value of 378 ng ml(−1), as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with ca. 50% inhibition at 30 mg/kg (p.o.).
Search related documents:
Co phrase search for related documents, hyperlinks ordered by date