Author: Yichun Cheng; Ran Luo; Kun Wang; Meng Zhang; Zhixiang Wang; Lei Dong; Junhua Li; Ying Yao; Shuwang Ge; Gang Xu
Title: Kidney impairment is associated with in-hospital death of COVID-19 patients Document date: 2020_2_20
ID: ahxnhutv_22
Snippet: Therefore, the kidney impairment may be caused by coronavirus entering the cells through ACE2 that are highly expressed in the kidney. Second, deposition of immune complexes of viral antigen or virus-induced specific immunological effector mechanisms (specific T lymphocyte or antibody) may damage the kidney. However, the data of kidney specimens from SARS patients showed normal glomerular histology with absence of electron-dense deposits, indicat.....
Document: Therefore, the kidney impairment may be caused by coronavirus entering the cells through ACE2 that are highly expressed in the kidney. Second, deposition of immune complexes of viral antigen or virus-induced specific immunological effector mechanisms (specific T lymphocyte or antibody) may damage the kidney. However, the data of kidney specimens from SARS patients showed normal glomerular histology with absence of electron-dense deposits, indicating the possibility of an active immunemediated glomerulonephritis was low. Thus, kidney histology of COVID-19 patients is All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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