Author: Hassaan Ahmed; Kajal Patel; Darren Greenwood; Stephen Halpin; Penny Lewthwaite; Abayomi Salawu; Lorna Eyre; Andrew Breen; Rory O'Connor; Anthony Jones; Manoj Sivan
Title: LONG-TERM CLINICAL OUTCOMES IN SURVIVORS OF CORONAVIRUS OUTBREAKS AFTER HOSPITALISATION OR ICU ADMISSION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF FOLLOW-UP STUDIES Document date: 2020_4_22
ID: bzc7luwj_17
Snippet: Respiratory compromise is one of the key physical issues in survivors. The impairment is mainly restrictive in nature with predominance of abnormalities in DLCO, VC and TLC compared to FEV1, thereby, supporting the etiopathology of acute respiratory distress syndrome with parenchymal infiltration caused by the infection. Even though lung function improves over time, the results from our meta-analysis showed that reduction in DLCO may still be pre.....
Document: Respiratory compromise is one of the key physical issues in survivors. The impairment is mainly restrictive in nature with predominance of abnormalities in DLCO, VC and TLC compared to FEV1, thereby, supporting the etiopathology of acute respiratory distress syndrome with parenchymal infiltration caused by the infection. Even though lung function improves over time, the results from our meta-analysis showed that reduction in DLCO may still be present in 11 to 45% of CoV survivors at 12 months. This is consistent with CT findings of other studies which have reported that pulmonary fibrosis can persist up to 7 years 29 . Pulmonary rehabilitation has been shown to improve QoL in other patients with fibrosis 43 but it is unknown whether this would be effective in COVID-19 survivors.
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