Author: Manickam, A.; Johnson, K. A.; Singh, R.; Wood, N.; Ku, E.; Cuppoletti, A.; McDermott, M.; Hassibi, A.
Title: Multiplex PCR CMOS Biochip for Detection of Upper Respiratory Pathogens including SARS-CoV-2 Cord-id: v1ludca5 Document date: 2021_1_1
ID: v1ludca5
Snippet: A 1024-pixel CMOS biochip for multiplex polymerase chain reaction application is presented. Biosensing pixels include 137dB DDR photosensors and an integrated emission filter with OD∼6 to perform real-time fluorescence-based measurements while thermocycling the reaction chamber with heating and cooling rates of > ±10°C/s. The surface of the CMOS IC is biofunctionalized with DNA capturing probes. The biochip is integrated into a fluidic consumable enabling loading of extracted nucleic acid sa
Document: A 1024-pixel CMOS biochip for multiplex polymerase chain reaction application is presented. Biosensing pixels include 137dB DDR photosensors and an integrated emission filter with OD∼6 to perform real-time fluorescence-based measurements while thermocycling the reaction chamber with heating and cooling rates of > ±10°C/s. The surface of the CMOS IC is biofunctionalized with DNA capturing probes. The biochip is integrated into a fluidic consumable enabling loading of extracted nucleic acid samples and the detection of upper respiratory pathogens, including SARS-CoV-2. © 2021 JSAP.
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