Author: Huijie Bian; Zhao-Hui Zheng; Ding Wei; Zheng Zhang; Wen-Zhen Kang; Chun-Qiu Hao; Ke Dong; Wen Kang; Jie-Lai Xia; Jin-Lin Miao; Rong-Hua Xie; Bin Wang; Xiu-Xuan Sun; Xiang-Min Yang; Peng Lin; Jie-Jie Geng; Ke Wang; Hong-Yong Cui; Kui Zhang; Xiao-Chun Chen; Hao Tang; Hong Du; Na Yao; Shuang-Shuang Liu; Lin-Na Liu; Zhe Zhang; Zhao-Wei Gao; Gang Nan; Qing-Yi Wang; Jian-Qi Lian; Zhi-Nan Chen; Ping Zhu
Title: Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial Document date: 2020_3_24
ID: 6g34qwer_40
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03.21.20040691 doi: medRxiv preprint facilitate the invasion of SARS-CoV-2 to lymphocytes by binding spike protein, suggesting that CD147 may be involved in lymphocytopenia. Meplazumab interrupted this process by preventing virus invasion to keep lymphocytes survived. Second, the meplazumab blocking CD147-CyPA interaction might contribute to lym.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03.21.20040691 doi: medRxiv preprint facilitate the invasion of SARS-CoV-2 to lymphocytes by binding spike protein, suggesting that CD147 may be involved in lymphocytopenia. Meplazumab interrupted this process by preventing virus invasion to keep lymphocytes survived. Second, the meplazumab blocking CD147-CyPA interaction might contribute to lymphocyte elevation in peripheral blood by inhibiting the lymphocyte accumulation in pulmonary organ.
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