Selected article for: "cytosolic dna and DNA cytosolic sensor"
Author: Smita Gopinath; Myoungjoo V. Kim; Tasfia Rakib; Patrick W. Wong; Michael van Zandt; Natasha A. Barry; Tsuneyasu Kaisho; Andrew L. Goodman; Akiko Iwasaki
Title: Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics
  • Document date: 2018_1_16
    • ID: dzorkks5_24
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/248617 doi: bioRxiv preprint ( Supplementary Fig. 5b,c) . By contrast, neomycin-treatment of STING knockout mice 222 resulted in robust antiviral protection with significantly suppressed viral replication and little 223 to no disease pathology ( Supplementary Fig. 5e,f) . These results indicate that the cytosolic 224 DNA sensor signaling pathway .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/248617 doi: bioRxiv preprint ( Supplementary Fig. 5b,c) . By contrast, neomycin-treatment of STING knockout mice 222 resulted in robust antiviral protection with significantly suppressed viral replication and little 223 to no disease pathology ( Supplementary Fig. 5e,f) . These results indicate that the cytosolic 224 DNA sensor signaling pathway is dispensable for ISG induction by neomycin, while RNA 225 sensor signaling pathways play a partial role in aminoglycoside-mediated ISG induction. Irf3 -/-Irf7 -/mice as compared to PBS-treated controls (Fig. 4g ) and this lack of ISG 245 induction resulted in lack of protection against HSV-2 infection (Fig. 4h,i) . Induction of 246

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