Author: Smita Gopinath; Myoungjoo V. Kim; Tasfia Rakib; Patrick W. Wong; Michael van Zandt; Natasha A. Barry; Tsuneyasu Kaisho; Andrew L. Goodman; Akiko Iwasaki
Title: Microbiota-independent antiviral protection conferred by aminoglycoside antibiotics Document date: 2018_1_16
ID: dzorkks5_19
Snippet: We previously showed that oral neomycin treatment renders Mx1 deficient mice 181 susceptible to influenza disease because it depletes gut commensal bacteria that normally 182 support the function of dendritic cells that prime CD8 T cells 18 with an otherwise lethal dose of hvPR8, with 50% of mice protected (Fig. 3b) . These 191 results demonstrate that mucosal application of a single dose of neomycin can result in 192 substantial protection again.....
Document: We previously showed that oral neomycin treatment renders Mx1 deficient mice 181 susceptible to influenza disease because it depletes gut commensal bacteria that normally 182 support the function of dendritic cells that prime CD8 T cells 18 with an otherwise lethal dose of hvPR8, with 50% of mice protected (Fig. 3b) . These 191 results demonstrate that mucosal application of a single dose of neomycin can result in 192 substantial protection against a highly virulent influenza A virus infection. 193
Search related documents:
Co phrase search for related documents- deficient mouse and single dose: 1, 2, 3
- deficient mouse and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- dendritic cell and single dose: 1, 2, 3
- dendritic cell and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
- gut commensal bacteria and influenza disease: 1
- gut commensal bacteria and virus infection: 1
- highly virulent influenza and influenza disease: 1, 2, 3
- highly virulent influenza and single dose: 1
- highly virulent influenza and virus infection: 1
- highly virulent influenza and virus infection highly virulent influenza: 1
- influenza disease and lethal dose: 1, 2, 3, 4, 5
- influenza disease and single dose: 1, 2, 3, 4, 5
- influenza disease and substantial protection: 1
- influenza disease and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- lethal dose and single dose: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- lethal dose and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46
- mucosal application and virus infection: 1, 2, 3
- neomycin single dose and single dose: 1
- neomycin treatment and oral neomycin treatment: 1
Co phrase search for related documents, hyperlinks ordered by date