Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_15
Snippet: We examined adaptation to a completely distinct environment by repeating the experiment on 189 our PVR-3T3 cell line [44, 45] . In this alternative species and cell type, we actually observed 190 greater fitness gain in the high fidelity 3D G64S variant relative to WT (0.121 per passage; mixed 191 linear effects model, p=0.0013). The larger fitness gain in 3T3 cells may reflect a larger supply 192 of beneficial, compensatory mutations given the l.....
Document: We examined adaptation to a completely distinct environment by repeating the experiment on 189 our PVR-3T3 cell line [44, 45] . In this alternative species and cell type, we actually observed 190 greater fitness gain in the high fidelity 3D G64S variant relative to WT (0.121 per passage; mixed 191 linear effects model, p=0.0013). The larger fitness gain in 3T3 cells may reflect a larger supply 192 of beneficial, compensatory mutations given the lower baseline fitness of 3D G64S in these cells.
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