Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_40
Snippet: In this proof of concept study, we demonstrate that mNGS can simultaneously detect pathogens and the host response in HCT patients with acute respiratory illnesses. When benchmarked against the conventional standard of care testing performed during the time of study enrollment, mNGS demonstrated 100% sensitivity for microbial detection and permitted identification of potential new viral and bacterial pathogens in six of 15 (40%) subjects with oth.....
Document: In this proof of concept study, we demonstrate that mNGS can simultaneously detect pathogens and the host response in HCT patients with acute respiratory illnesses. When benchmarked against the conventional standard of care testing performed during the time of study enrollment, mNGS demonstrated 100% sensitivity for microbial detection and permitted identification of potential new viral and bacterial pathogens in six of 15 (40%) subjects with otherwise negative testing. We observed that the presence of respiratory pathogens was characterized by increased expression of host immune response genes and lower airway microbial diversity. Our results suggest that simultaneous mNGS detection of respiratory pathogens, the host's immunologic response and the airway microbiome may provide complementary data that could inform the clinical significance of a detected pathogen.
Search related documents:
Co phrase search for related documents- acute respiratory illness and care testing: 1, 2, 3, 4, 5, 6
- acute respiratory illness and clinical significance: 1, 2, 3, 4, 5
- acute respiratory illness and concept study: 1, 2
- acute respiratory illness and concept study proof: 1
- acute respiratory illness and detected pathogen: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute respiratory illness and host response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- bacterial viral pathogen and conventional standard: 1
- bacterial viral pathogen and detected pathogen: 1, 2, 3, 4, 5, 6, 7, 8
- bacterial viral pathogen and host response: 1
- bacterial viral pathogen and increase expression: 1
- care testing and clinical significance: 1, 2, 3, 4, 5, 6
- care testing and concept study: 1, 2, 3
- care testing and concept study proof: 1, 2
- care testing and detected pathogen: 1, 2
- care testing and host response: 1, 2, 3
- clinical significance and detected pathogen: 1, 2, 3
- clinical significance and host response: 1, 2, 3, 4
- clinical significance and immune response gene: 1
- clinical significance and increase expression: 1, 2
Co phrase search for related documents, hyperlinks ordered by date