Selected article for: "locus control and long distance"
Author: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan
Title: A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors
  • Document date: 2020_4_15
    • ID: 5r0u2mmo_22
    Snippet: The wider ACE2 locus (chrX: 15,519,996-15,643,106; GRCh38/hg38) sits within a 151 topologically associating domain (TAD) that is conserved across some tissues, e.g. IMR90 (Fig 152 1A ). Therefore, it was not surprising that we identified control elements within this ACE2 locus 153 ( Fig 1A) . The distribution of targets for the putative control elements we identified is consistent 154 with previous studies that show that while the majority of .....
    Document: The wider ACE2 locus (chrX: 15,519,996-15,643,106; GRCh38/hg38) sits within a 151 topologically associating domain (TAD) that is conserved across some tissues, e.g. IMR90 (Fig 152 1A ). Therefore, it was not surprising that we identified control elements within this ACE2 locus 153 ( Fig 1A) . The distribution of targets for the putative control elements we identified is consistent 154 with previous studies that show that while the majority of significant eQTLs fall within 100 kb 155 of the transcription start site of a gene, only 60% of all eQTLs are upstream of the gene they 156 regulate [32] . Notable amongst the elements we identified are long distance trans-regulatory 157 interactions involving: 1) rs1399200:VPS13C (chr15:61,852,389-62,060,473; encodes 158 vacuolar protein sorting-associated protein 13C); and 2) rs6632680:PHKA2 (chrX:18,892,300-159 18,984,598; encodes phosphorylase kinase regulatory subunit alpha 2) (S2 Table) . 160

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