Selected article for: "high throughput and host virus"
Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus
  • Document date: 2020_2_5
    • ID: b4mdiont_67
    Snippet: We collected HCoV-host protein interactions from various literatures based on our sizeable efforts. The HCoV-associated host proteins of several HCoVs, including SARS-CoV, MERS-CoV, IBV, MHV, HCoV-229E, and HCoV-NL63 were pooled. These proteins were either the direct targets of HCoV proteins or were involved in critical pathways of HCoV infection identified by multiple experimental sources, including high throughput yeast-two-hybrid (Y2H) systems.....
    Document: We collected HCoV-host protein interactions from various literatures based on our sizeable efforts. The HCoV-associated host proteins of several HCoVs, including SARS-CoV, MERS-CoV, IBV, MHV, HCoV-229E, and HCoV-NL63 were pooled. These proteins were either the direct targets of HCoV proteins or were involved in critical pathways of HCoV infection identified by multiple experimental sources, including high throughput yeast-two-hybrid (Y2H) systems, viral protein pull-down assay, in vitro coimmunoprecipitation and RNA knock down experiment. In total, the virus-host interaction network included 6 HCoVs with 119 host proteins (Supplementary Table S3 ).

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