Selected article for: "antagonist function and IFN antagonist function"
Author: MJ Morwitzer; A Corona; L Zinzula; E Fanunza; C Nigri; S Distinto; C Vornholt; V Kumar; E Tramontano; SP Reid
Title: Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions
  • Document date: 2019_8_7
    • ID: cbyzdnrp_95
    Snippet: prevents kinase activation via steric inhibition (Prins et al., 2009 ). Even so, in our study here the 538 VP35-S129A mutant impaired replication function but did not affect VP35 IFN antagonist 539 function. Given the high virulence of EBOV infection and the multifunctional nature of VP35, it 540 seems unlikely that VP35 phosphorylation by IKKε and TBK-1 would detrimentally affect virus 541 . CC-BY-NC 4.0 International license is made available .....
    Document: prevents kinase activation via steric inhibition (Prins et al., 2009 ). Even so, in our study here the 538 VP35-S129A mutant impaired replication function but did not affect VP35 IFN antagonist 539 function. Given the high virulence of EBOV infection and the multifunctional nature of VP35, it 540 seems unlikely that VP35 phosphorylation by IKKε and TBK-1 would detrimentally affect virus 541 . CC-BY-NC 4.0 International license is made available under a

    Search related documents:
    Co phrase search for related documents
    • cc NC International license and replication function: 1
    • cc NC International license available and International license: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • EBOV infection and International license: 1
    • EBOV infection and replication function: 1
    • impaired replication function and replication function: 1, 2
    • International license and replication function: 1