Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_4
Snippet: Previously, microarray approaches proved useful for broadening the scope of pathogens detectable in a single LRTI assay; some microarrays have even incorporated conserved sequences from all known viruses, allowing detection of novel viral strains (11) . Metagenomic next-generation sequencing (mNGS) inherently offers enhanced diagnostic capabilities by providing a culture-independent, comprehensive measurement of the microbial composition of clini.....
Document: Previously, microarray approaches proved useful for broadening the scope of pathogens detectable in a single LRTI assay; some microarrays have even incorporated conserved sequences from all known viruses, allowing detection of novel viral strains (11) . Metagenomic next-generation sequencing (mNGS) inherently offers enhanced diagnostic capabilities by providing a culture-independent, comprehensive measurement of the microbial composition of clinical samples (12, 13) . This technology permits the simultaneous detection of bacterial, viral and fungal pathogens without introducing bias associated with fixed-target PCR or serologic All rights reserved. No reuse allowed without permission.
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