Author: William T Gibson; Daniel M Evans; Jianghong An; Steven JM Jones
Title: ACE 2 Coding Variants: A Potential X-linked Risk Factor for COVID-19 Disease Document date: 2020_4_14
ID: 05w8tv8x_4
Snippet: The human ACE2 protein has recently been shown to serve as the binding site and point-of-72 entry of SARS-CoV-2 into human cells. 16 ACE2 had also previously been shown to bind SARS-CoV, 17 73 a related virus that caused serious respiratory infections in humans in the early 2000s. The viral Spike 74 glycoproteins ("S" proteins) of SARS-CoV 18 and SARS-CoV-2 19 bind physically to the peptidase 75 domain of ACE2 using their receptor binding domains.....
Document: The human ACE2 protein has recently been shown to serve as the binding site and point-of-72 entry of SARS-CoV-2 into human cells. 16 ACE2 had also previously been shown to bind SARS-CoV, 17 73 a related virus that caused serious respiratory infections in humans in the early 2000s. The viral Spike 74 glycoproteins ("S" proteins) of SARS-CoV 18 and SARS-CoV-2 19 bind physically to the peptidase 75 domain of ACE2 using their receptor binding domains (RBD), thereby enabling viral internalization. 76
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