Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_89
Snippet: We developed the following model to measure the effective bottleneck that restricts poliovirus 931 populations between the site of inoculation and the central nervous system. We applied a 932 simple probabilistic model to data described in [48] . In this study, 27 mice were infected with 2 x 933 10 7 PFU of poliovirus (2-5 fold higher than the LD 50 in this particular mouse model). The inocula 934 consisted of 4 subpopulations at equal concentrat.....
Document: We developed the following model to measure the effective bottleneck that restricts poliovirus 931 populations between the site of inoculation and the central nervous system. We applied a 932 simple probabilistic model to data described in [48] . In this study, 27 mice were infected with 2 x 933 10 7 PFU of poliovirus (2-5 fold higher than the LD 50 in this particular mouse model). The inocula 934 consisted of 4 subpopulations at equal concentrations, each tagged with a neutral sequence bar 935 code. In separate experiments, the authors showed that all 4 bar codes were present at the site 936 of infection and that all four bar codes were capable of replicating simultaneously in the brain.
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