Selected article for: "blood flow and fluid homeostasis"
Author: Tayaza Fadason; Sreemol Gokuladhas; Evgeniia Golovina; Daniel Ho; Sophie Farrow; Denis Nyaga; Hong Pan; Neerja Karnani; Conroy Wong; Antony Cooper; William Schierding; Justin M. O’Sullivan
Title: A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors
  • Document date: 2020_4_15
    • ID: 5r0u2mmo_2
    Snippet: virus. Angiotensin-converting enzyme 2 (ACE2) has been identified as the main receptor for 25 entry of both SARS-CoV and SARS-CoV-2 into human cells. ACE2 is normally expressed in 26 cardiovascular and lung type II alveolar epithelial cells, where it positively modulates the RAS 27 system that regulates blood flow, pressure, and fluid homeostasis. Thus, virus-induced 28 reduction of ACE2 gene expression is considered to make a significant contrib.....
    Document: virus. Angiotensin-converting enzyme 2 (ACE2) has been identified as the main receptor for 25 entry of both SARS-CoV and SARS-CoV-2 into human cells. ACE2 is normally expressed in 26 cardiovascular and lung type II alveolar epithelial cells, where it positively modulates the RAS 27 system that regulates blood flow, pressure, and fluid homeostasis. Thus, virus-induced 28 reduction of ACE2 gene expression is considered to make a significant contribution to severe 29 acute respiratory failure. Chromatin remodelling plays a significant role in the regulation of 30 ACE2 gene expression and the activity of regulatory elements within the genome. 31

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