Author: Danielle E Anderson; Jin Cui; Qian Ye; Baoying Huang; Wenhong Zu; Jing Gong; Weiqiang Liu; So Young Kim; Biao Guo Yan; Kristmundur Sigmundsson; Xiao Fang Lim; Fei Ye; Peihua Niu; Xuming Zhou; Wenjie Tan; Lin-Fa Wang; Xu Tan
Title: Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy Document date: 2020_3_30
ID: 0l33i6s4_39
Snippet: Carolacton, a natural product derived from bacteria, has recently been identified as a potent 27 inhibitor of MTHFD1 33 . We tested the effect of this compound on viral replication. Carolacton 28 inhibited Zika virus and mumps virus replication in PaKi cells in a dose dependent fashion (Fig. 29 4a, 4b and 4c ). The inhibition was achieved at doses with little cytotoxicity (Fig. 4a) . 30.....
Document: Carolacton, a natural product derived from bacteria, has recently been identified as a potent 27 inhibitor of MTHFD1 33 . We tested the effect of this compound on viral replication. Carolacton 28 inhibited Zika virus and mumps virus replication in PaKi cells in a dose dependent fashion (Fig. 29 4a, 4b and 4c ). The inhibition was achieved at doses with little cytotoxicity (Fig. 4a) . 30
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