Neural organization of speech production: A lesion-based study of error patterns in connected speech

Brielle C Stark; Alexandra Basilakos; Gregory Hickok; Chris Rorden; Leonardo Bonilha; Julius Fridriksson

If indeed there is disparity between the distributions of paraphasias in connected speech and naming, it raises the question regarding the extent to which neural mechanisms underlying single-word paraphasias during connected speech and confrontation naming are similar. Few studies have evaluated the neural correlates of paraphasias made during connected speech. In 70 participants with primary progressive . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/544841 doi: bioRxiv preprint 5 aphasia, Wilson and colleagues associated phonemic paraphasias made during a connected speech task with atrophy of the left superior temporal gyrus (Wilson et al., 2010) . Meanwhile, studies of naming in poststroke aphasia have localized phonemic paraphasias and speech production errors to dorsal stream structures (Schwartz et al., 2012; Dell et al., 2013) . Whilst the methodology used, and the population studied across these examples, are not directly comparable, the results of these investigations encourage further evaluation of the neural structures underlying connected speech compared with naming paraphasias.