Neural organization of speech production: A lesion-based study of error patterns in connected speech

Brielle C Stark; Alexandra Basilakos; Gregory Hickok; Chris Rorden; Leonardo Bonilha; Julius Fridriksson

We evaluated brain damage significantly associated with each paraphasia type in the CS and the PNT task groups using VLSM. Figure 4A shows the VLSM results for each paraphasia type by task group, showing the voxelwise and cluster thresholded results. Table 3 serves as a complement to Figure 4A , presenting the maximum z-value and coordinates of voxels that, when damaged, significantly associated with paraphasia type by task group. Overall, for the CS task group, unrelated paraphasias were associated with a cluster of 14208 lesioned voxels in left hemisphere temporoparietal cortex; semantically related paraphasias were associated with a cluster of 19135 lesioned voxels in left hemisphere temporoparietal cortex; neologistic paraphasias were associated with a cluster of 14718 lesioned voxels in left hemisphere frontoparietal cortex and phonemically related paraphasias (when controlling also for apraxia of speech) were not associated with a significant cluster of damage. For the PNT task group, unrelated paraphasias were associated with a cluster of 19873 lesioned voxels in left hemisphere temporoparietal cortex and semantically related . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/544841 doi: bioRxiv preprint paraphasias were associated with a cluster of 20978 lesioned voxels in left hemisphere temporoparietal cortex.