Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response

Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer

To recapitulate the pharmacokinetics of HCQ, we developed a model on pharmacokinetics models of chloroquine (CQ), as HCQ is a derivate of CQ and has the same active metabolites (44) . In this four-compartment model, the drug gets absorbed from the gut compartment ( = ) at rate : and enters the central compartment ( 9 , with volume ) ), where it is eliminated with at a rate < . The rate constants )8 and )> represent the movement of the drug from the central compartment to the first peripheral compartment ( 8 , volume 8 ) and the first peripheral compartment ( > , volume > ), respectively. Similarly, the movement of the drug from compartments 8 and > to the central compartment is modelled using 8) and >) , respectively. The modeling equations representing the amount of drug in each compartment is given by, . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity. We fit this model to the PK data using a non-linear least squares approach.