Author: Lazzerini, M.; Sforzi, I.; Trapani, S.; Biban, P.; Salvigni, D.; Mariani, I.; Villa, G.; Tibaldi, J.; Bertacca, L.; Felici, E.; Perricone, G.; Parrino, R.; Gioe', C.; Lega, S.; Conte, M.; Marchetti, F.; Magista, A.; Berlese, P.; Martelossi, S.; Vaienti, F.; Valletta, E.; Mauro, M.; Dall Amico, R.; Fasoli, S.; Gatto, A.; Chiaretti, A.; Dragovic, D.; Pascolo, P.; Pilotto, C.; Liguoro, I.; Miorin, E.; Saretta, F.; Trobia, G.; Di Stefano, A.; Orlandi, A.; Cardinale, F.; Lubrano, R.; Testa, A.; Binotti, M.; Moressa, V.; Barbi, E.; Armocida, B.
Title: Characteristics and risk factors for SARS-CoV-2 among children in Italy: a cross-sectional study in 20 pediatric centers Cord-id: ns2emsrp Document date: 2021_3_17
ID: ns2emsrp
Snippet: Background: No study has described factors associated with COVID-19 diagnosis in children. Aim: Describe characteristics and risk factors for COVID-19 diagnosis in children tested in 20 pediatric centers across Italy. Methods: Cases aged 0-18 years tested for SARS-CoV-2 between February 23 and May 24 2020 were included. Our primary analysis focused on children tested because of COVID-19 suggestive symptoms. Results: Among 2494 children tested for SARS-CoV-2, 2148 (86.1%) had symptoms suggestive
Document: Background: No study has described factors associated with COVID-19 diagnosis in children. Aim: Describe characteristics and risk factors for COVID-19 diagnosis in children tested in 20 pediatric centers across Italy. Methods: Cases aged 0-18 years tested for SARS-CoV-2 between February 23 and May 24 2020 were included. Our primary analysis focused on children tested because of COVID-19 suggestive symptoms. Results: Among 2494 children tested for SARS-CoV-2, 2148 (86.1%) had symptoms suggestive of COVID-19. Clinical presentation of SARS-CoV-2 included, beside fever (82.4%) and respiratory signs or symptoms (60.4%), also gastrointestinal (18.2%), neurological (18.9%), cutaneous (3.8%) and other flu-like presentations (17.8%). In multivariate analysis, factors significantly associated with SARS-CoV-2 were: exposure history (adjusted OR 39.83 95%CI 17.52-90.55 p<0.0001), cardiac disease (adjusted OR 3.10 95%CI 1.19- 5.02 p<0.0001), fever (adjusted OR 3.05 % 95% CI 1.67-5.58 p=0.0003), and anosmia/ageusia (OR 4.08 95%CI 1.69 -9.84 p=0.002). Among 190 (7.6%) children diagnosed with SARS-CoV-2, only four (2.1%) required respiratory support and two (1.1%) were admitted in ICU, while 100% recovered. Conclusion: Recommendations for SARS-CoV-2 testing in children should be updated based on the evidence of broader clinical features. Exposure history, fever, and anosmia/ageusia are strong risk factors for COVID-19 in children, while other symptoms do not seem helping discriminating in between the SARS-CoV-2 positive and the negative cases. This study confirm that COVID-19 is a mild disease in the general population of children in Italy. Further studies are needed to understand the risk, clinical spectrum and outcomes of COVID-19 in children with specific preexisting conditions.
Search related documents:
Co phrase search for related documents- absolute number and local policy: 1
- absolute number and logistic regression: 1, 2, 3, 4, 5
- absolute number and longitudinal study: 1
- absolute number and lung ultrasound: 1
- acknowledge important and local policy: 1
- acknowledge important and longitudinal study: 1
- acute respiratory distress syndrome and local protocol: 1, 2, 3, 4, 5
- acute respiratory distress syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute respiratory distress syndrome and logistic regression model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- acute respiratory distress syndrome and longitudinal study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- acute respiratory distress syndrome and lung affect: 1, 2, 3, 4, 5, 6, 7
- acute respiratory distress syndrome and lung auscultation: 1, 2, 3, 4
- acute respiratory distress syndrome and lung ultrasound: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40
- local epidemiology and longitudinal study: 1
- local policy and logistic regression: 1
- local policy and longitudinal study: 1
- local protocol and logistic regression: 1
- local protocol and lung ultrasound: 1, 2
- logistic regression and longitudinal study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
Co phrase search for related documents, hyperlinks ordered by date