Multisystem Inflammatory Syndrome in Children With COVID-19 in Mumbai, India.

Jain, Shreepal; Sen, Supratim; Lakshmivenkateshiah, Srinivas; Bobhate, Prashant; Venkatesh, Sumitra; Udani, Soonu; Shobhavat, Laxmi; Andankar, Parmanand; Karande, Tanuja; Kulkarni, Snehal

OBJECTIVE We describe the presentation, treatment and outcome of children with multisystem inflammatory syndrome with COVID-19 (MIS-C) in Mumbai metropolitan area in India. METHODS This is an observational study conducted at four tertiary hospitals in Mumbai. Parameters including demographics, symptomatology, laboratory markers, medications and outcome were obtained from patient hospital records and analyzed in patients treated for MIS-C (as per WHO criteria) from 1 May, 2020 to 15 July, 2020. RESULTS 23 patients (11 males) with median (range) age of 7.2 (0.8-14) years were included. COVID19 RT PCR or antibody was positive in 39.1% and 30.4%, respectively; 34.8% had a positive contact. 65% patients presented in shock; these children had a higher age (P=0.05), and significantly higher incidence of myocarditis with elevated Troponin, NT pro BNP and LV dysfunction, along with significant neutrophilia and lymphopenia, as compared to those without shock. Coronary artery dilation was seen in 26% patients overall. Steroids were used most commonly for treatment (96%), usually along with intravenous immunoglobulin (IVIg) (65%). Outcome was good with only one death. CONCLUSION Initial data on MIS-C from India is presented. Further studies and longer surveillance of patients with MIS-C are required to improve our diagnostic, treatment and surveillance criteria.