Author: Lyudmila Kovalchuke; Eugene V. Mosharov; Oren A. Levy; Lloyd A. Greene
Title: Stress-induced phospho-ubiquitin formation causes parkin degradation Document date: 2018_12_5
ID: ceepyyxj_1
Snippet: Parkinson's disease (PD) is a debilitating neurodegenerative disorder, affecting roughly 2% of those over the age of 80 [1] . Though most cases of PD appear to be "sporadic", a minority of cases have a clear autosomal dominant or recessive inheritance pattern [2] . The most common known cause of autosomal recessive PD is homozygous inactivation of PARK2, which encodes the E3 ubiquitin ligase parkin [3] . Parkin has been demonstrated to promote ce.....
Document: Parkinson's disease (PD) is a debilitating neurodegenerative disorder, affecting roughly 2% of those over the age of 80 [1] . Though most cases of PD appear to be "sporadic", a minority of cases have a clear autosomal dominant or recessive inheritance pattern [2] . The most common known cause of autosomal recessive PD is homozygous inactivation of PARK2, which encodes the E3 ubiquitin ligase parkin [3] . Parkin has been demonstrated to promote cell survival in many different contexts [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] . There is also evidence that parkin loss may play a role in the pathogenesis of sporadic PD [21] [22] [23] . As such, strategies aimed at upregulating parkin levels or maintaining it in an active state hold therapeutic promise for sporadic PD [16] , [24] [25] [26] .
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