Author: Zhang, Chen-xi; Tu, Ye; Kong, De-pei; Li, Yinghua; Chen, Da-gui; Zhang, Wan-nian; Su, Li; Zhuang, Chun-lin; Wang, Zhi-bin
Title: Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects Cord-id: h8z534qw Document date: 2020_7_14
ID: h8z534qw
Snippet: Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus −2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe COVID-19 patients, and the macrophage is recognized as the direct host cell of SARS-CoV-2 and potential drivers of CSS. In the present study, peramivir was identified to reduce TNF-α by partly intervention of NF-κB activity in LPS-induced macro
Document: Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus −2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe COVID-19 patients, and the macrophage is recognized as the direct host cell of SARS-CoV-2 and potential drivers of CSS. In the present study, peramivir was identified to reduce TNF-α by partly intervention of NF-κB activity in LPS-induced macrophage model. In vivo, peramivir reduced the multi-cytokines in serum and bronchoalveolar lavage fluid (BALF), alleviated the acute lung injury and prolonged the survival time in mice. In human peripheral blood mononuclear cells (hPBMCs), peramivir could also inhibit the release of TNF-α. Collectively, we proposed that peramivir might be a candidate for the treatment of COVID-19 and other infections related CSS. Graphic Abstract
Search related documents:
Co phrase search for related documents- acute ards respiratory distress syndrome and lps injection: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and lps stimulate: 1
- acute ards respiratory distress syndrome and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute ards respiratory distress syndrome and lung injury score: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- acute ards respiratory distress syndrome and lung lesion: 1
- acute respiratory and lps induce: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory and lps injection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute respiratory and lps stimulate: 1
- acute respiratory and luciferase system: 1, 2
- acute respiratory and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory and lung injury score: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- acute respiratory and lung lesion: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- acute respiratory syndrome coronavirus and lps induce: 1
- acute respiratory syndrome coronavirus and luciferase system: 1, 2
- acute respiratory syndrome coronavirus and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome coronavirus and lung injury score: 1, 2
- acute respiratory syndrome coronavirus and lung lesion: 1, 2, 3, 4, 5, 6, 7, 8, 9
- lps induce and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- lps induce and lung injury score: 1
Co phrase search for related documents, hyperlinks ordered by date