Author: Zhiheng Xu; Jianmeng Zhou; Yongbo Huang; Xuesong Liu; Yonghao Xu; Sibei Chen; Dongdong Liu; Zhimin Lin; Xiaoqing Liu; Yimin Li
Title: The efficacy of convalescent plasma for the treatment of severe influenza Document date: 2020_2_23
ID: 4pe9o59g_38
Snippet: Hung et al had found that H1N1 viral loads were significantly lower in patients after convalescent plasma infused than in the control group. Furthermore, the cytokines, including IL-1ra, IL-10, and TNF-a, were also lower in the convalescent plasma treatment group (17) . However, in another large clinical trial, overall viral loads were decreased in both H-IVIG and placebo group during the first 3 days (p=0.49). There was 16% of H-IVIG group and 2.....
Document: Hung et al had found that H1N1 viral loads were significantly lower in patients after convalescent plasma infused than in the control group. Furthermore, the cytokines, including IL-1ra, IL-10, and TNF-a, were also lower in the convalescent plasma treatment group (17) . However, in another large clinical trial, overall viral loads were decreased in both H-IVIG and placebo group during the first 3 days (p=0.49). There was 16% of H-IVIG group and 20% of placebo group had no detectable virus (p=0.15) after infusion. For subgroup with influenza B, the decline in viral loads was greater for the H-IVIG group than for the placebo group (p=0·053) (15) . In addition, there was no significant difference in influenza A and B viral loads and the time to virus becoming undetectable (19) ( Table 2) .
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