Author: Laresgoiti-Servitje, Estibalitz; Cardona-Pérez, Jorge Arturo; Hernández-Cruz, Rosa Gabriela; Helguera-Repetto, Addy Cecilia; Valdespino-Vázquez, MarÃa Yolotzin; Moreno-Verduzco, Elsa Romelia; Villegas-Mota, Isabel; Acevedo-Gallegos, Sandra; RodrÃguez-Bosch, Mario; León-Juárez, Moisés; Aguinaga-RÃos, Mónica; Coronado-Zarco, Irma; Ortiz-Calvillo, Alejandro; Rivera-Rueda, MarÃa Antonieta; Valencia-Contreras, Carolina; Gómez-Sousa, MarÃa de Lourdes; Solis-Paredes, Mario; Rodriguez-Aldama, Juan Carlos; Galván-Contreras, Rafael; Figueroa-Damián, Ricardo; Cortés-Bonilla, Manuel; Estrada-Gutierrez, Guadalupe; Espino-y-Sosa, Salvador; Irles, Claudine
Title: COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes Cord-id: pzkagbwn Document date: 2021_9_21
ID: pzkagbwn
Snippet: (1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (C(T)) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and C(T) values were assessed by logistic regression model
Document: (1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (C(T)) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and C(T) values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between C(T) values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low C(T)s (<25; p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or C(T) values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.
Search related documents:
Co phrase search for related documents- absence presence and adjusted ci: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- absence presence and liver injury: 1, 2, 3, 4, 5, 6
- absence presence and liver kidney: 1, 2
- absence presence and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- absence presence and logistic regression estimate: 1, 2, 3
- absence presence and logistic regression model: 1, 2, 3, 4, 5, 6, 7
- absence presence and logistic regression variable: 1, 2, 3
- acute respiratory syndrome and adjusted ci: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and live birth: 1, 2, 3, 4, 5, 6
- acute respiratory syndrome and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and liver kidney: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and liver kidney cardiac: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- acute respiratory syndrome and liver kidney cardiac digestive tract injury: 1, 2
- acute respiratory syndrome and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and logistic regression estimate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute respiratory syndrome and logistic regression model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and logistic regression variable: 1, 2, 3, 4, 5, 6, 7
- adjusted ci and live birth: 1, 2, 3, 4
- adjusted ci and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
Co phrase search for related documents, hyperlinks ordered by date