Author: Habtemariam, Solomon; Nabavi, Seyed fazel; Banach, Maciej; Berindan-Neagoe, Ioana; kasturi Sarkar,; Sil, Parames C.; Nabavi, Seyed Mohammad
Title: Should we try SARS-CoV-2 Helicase Inhibitors for COVID-19 Therapy? Cord-id: qjpb51gm Document date: 2020_5_31
ID: qjpb51gm
Snippet: The discovery of new drugs for treating the new coronavirus (SARS-CoV-2) or repurposing those already in use for other viral infections is possible through understanding of the viral replication cycle and pathogenicity. This article highlights the advantage of targeting one of the non-structural proteins, helicase (nsp13), over other SARS-CoV-2 proteins. Highlighting the experience gained from targeting Nsp13 in similar coronaviruses (SARS-CoV and MERS) and known inhibitors, the article calls fo
Document: The discovery of new drugs for treating the new coronavirus (SARS-CoV-2) or repurposing those already in use for other viral infections is possible through understanding of the viral replication cycle and pathogenicity. This article highlights the advantage of targeting one of the non-structural proteins, helicase (nsp13), over other SARS-CoV-2 proteins. Highlighting the experience gained from targeting Nsp13 in similar coronaviruses (SARS-CoV and MERS) and known inhibitors, the article calls for research on helicase inhibitors as potential COVID-19 therapy.
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