Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets Document date: 2020_4_15
ID: anedg12x_1
Snippet: In December 2019, a novel coronavirus named SARS-CoV-2 first reported in Wuhan, China, 30 emerged and rapidly spread to numerous other countries globally, causing the current 31 pandemic. SARS-CoV-2 causes acute infection of the respiratory tract (COVID-19) that can 32 result in severe disease and lethality. Currently, there is no approved antiviral drug for 33 treating COVID-19 patients and there is an urgent need for specific antiviral therapie.....
Document: In December 2019, a novel coronavirus named SARS-CoV-2 first reported in Wuhan, China, 30 emerged and rapidly spread to numerous other countries globally, causing the current 31 pandemic. SARS-CoV-2 causes acute infection of the respiratory tract (COVID-19) that can 32 result in severe disease and lethality. Currently, there is no approved antiviral drug for 33 treating COVID-19 patients and there is an urgent need for specific antiviral therapies and 34
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