Author: David N. Frick; Rajdeep S. Virdi; Nemanja Vuksanovic; Narayan Dahal; Nicholas R Silvaggi
Title: Variable Macro X Domain of SARS-CoV-2 Retains the Ability to Bind ADP-ribose Document date: 2020_4_2
ID: 02q9y011_5
Snippet: At the other end of the spectrum are the nsp3 proteins, which are notably more different in the two SARS viruses. Nsp3 is a large multidomain membrane-bound protein, 6 and its clearest role in viral replication is cleaving the rep polyprotein. Over 17% of the amino acids in the nsp3 protease domain differ between SARS-CoV-1 and SARS-CoV-2. Other parts of nsp3 are even more variable, like the macrodomains that lie N-terminal to the nsp3 protease d.....
Document: At the other end of the spectrum are the nsp3 proteins, which are notably more different in the two SARS viruses. Nsp3 is a large multidomain membrane-bound protein, 6 and its clearest role in viral replication is cleaving the rep polyprotein. Over 17% of the amino acids in the nsp3 protease domain differ between SARS-CoV-1 and SARS-CoV-2. Other parts of nsp3 are even more variable, like the macrodomains that lie N-terminal to the nsp3 protease domain. Macrodomains consist of four helices that surround a mixed beta sheet. A ligand-binding pocket that typically binds ADP-ribose or related compounds lies between the helices and the sheet. 7 SARS-CoV-1 has three macrodomains in tandem, but only the first binds ADP ribose. The amino acid sequences of this macro X domain differ by 26% between SARS-CoV-1 and SARS-CoV-2 ( Fig. 1) .
Search related documents:
Co phrase search for related documents- acid sequence and amino acid: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acid sequence and amino macro acid sequence: 1
- acid sequence and beta sheet: 1, 2, 3, 4
- acid sequence and clear role: 1
- acid sequence and macro acid sequence: 1
- acid sequence and membrane bind: 1
- acid sequence and membrane bind protein: 1
- acid sequence and protease domain: 1, 2, 3
- ADP ribose and amino acid: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- ADP ribose and amino macro acid sequence: 1
- ADP ribose and bind ADP ribose: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- ADP ribose and macro acid sequence: 1
- ADP ribose and protease domain: 1, 2
- amino acid and beta sheet: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- amino acid and bind ADP ribose: 1, 2
- amino acid and clear role: 1
- amino acid and ligand bind: 1
- amino acid and macro acid sequence: 1
- amino acid and membrane bind: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date