Single Nucleus Multiomic Profiling Reveals Age-Dynamic Regulation of Host Genes Associated with SARS-CoV-2 Infection

Allen Wang; Joshua A Chiou; Olivier B Poirion; Justin Buchanan; Michael J Valdez; Jamie M Verheyden; Xiaomeng Hou; Minzhe Guo; Jacklyn M Newsome; Parul Kudtarkar; Dina A Faddah; Kai Zhang; Randee E Young; Justinn Barr; Ravi Misra; Heidie Huyck; Lisa Rogers; Cory Poole; Jeffery A Whitsett; Gloria Pryhuber; Yan Xu; Kyle J Gaulton; Sebastian Preissl; Xin Sun

were associated with phenotypes related to respiratory function, infection, medication use 413 or other traits using GWAS data generated using the UK Biobank (UKBB) (Sudlow et al., 414 2015) . Across the 11 variants tested for association in UKBB data, the most significant 415 association was between rs35074065 and emphysema (p=5.64×10 -7 ) ( Figure 4C ). This 416 variant was also more nominally associated (p<0.005) with asthma (p=6.7×10 -4 ) and 417 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.12.037580 doi: bioRxiv preprint influenza vaccine (p=1.76×10 -3 ). Furthermore, the majority of tested variants (8/11) were 418 nominally associated (p<1x0 -3 ) with at least one phenotype related to respiratory function 419 or respiratory medication use including salmeterol + fluticasone propionate, which is 420 commonly used to treat asthma and COPD (rs7279188 p=1.3×10 -5 ), bacterial pneumonia 421 (rs2838089 p=2.4×10 -4 ), bronchiectasis (rs9974995 p=7.1×10 -4 , rs568517 p=8.1×10 -4 ), 422