Author: Blumberg, Emily A.; Manuel, Oriol; Sester, Martina; Ison, Michael G.
Title: The future of SARSâ€CoVâ€2 vaccines in transplant recipients: To be determined Cord-id: 5bug414c Document date: 2021_4_19
ID: 5bug414c
Snippet: The increasing availability of SARS-CoV-2 vaccines has been heralded as the intervention that will finally stem the COVID-19 pandemic. However, it is unclear how immunosuppressed patients, including solid organ transplant recipients will respond to vaccination. Given the smaller numbers of affected patients, compared with vaccine trials in the general population, the changing epidemiology of the pandemic with the emergence of concerning viral variants, and greater precautionary measure adherence
Document: The increasing availability of SARS-CoV-2 vaccines has been heralded as the intervention that will finally stem the COVID-19 pandemic. However, it is unclear how immunosuppressed patients, including solid organ transplant recipients will respond to vaccination. Given the smaller numbers of affected patients, compared with vaccine trials in the general population, the changing epidemiology of the pandemic with the emergence of concerning viral variants, and greater precautionary measure adherence, it may be difficult to determine efficacy in this population. Consequently, assessment of immunogenicity, including measurement of antibodies to the spike receptor-binding domain and evaluation of cellular responses, provides important information to define the host response to this vaccine.
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