Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy Document date: 2020_2_27
ID: egntml7e_83
Snippet: Sepsis is a life-threatening condition caused by a dysregulated host response to infection (Singer et al., 2016) . In the last decade, reversing sepsis-induced immunosuppression becomes the focus of sepsis research instead of targeting cytokine storm (Cohen, 2002; Hotchkiss, Monneret & Payen, 2013a; Kox, Volk, Kox & Volk, 2000; Prucha, Zazula & Russwurm, 2017) . However, drugs in current clinical trials, such as IL-7, anti-programmed cell death r.....
Document: Sepsis is a life-threatening condition caused by a dysregulated host response to infection (Singer et al., 2016) . In the last decade, reversing sepsis-induced immunosuppression becomes the focus of sepsis research instead of targeting cytokine storm (Cohen, 2002; Hotchkiss, Monneret & Payen, 2013a; Kox, Volk, Kox & Volk, 2000; Prucha, Zazula & Russwurm, 2017) . However, drugs in current clinical trials, such as IL-7, anti-programmed cell death receptor-1 (anti-PD-1) and anti-PD-L1 antibodies, probably only for the immunosuppression stage of sepsis (Hotchkiss, Monneret & Payen, 2013a; Prucha, Zazula & Russwurm, 2017) , and its clinical efficacy is yet to be proven.
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