Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates Document date: 2020_4_18
ID: 6ne76rh1_5
Snippet: The host range of SARS-CoV-2 may be extremely broad due to the conservation of ACE2 in mammals (2, 13) and its expression on ciliated bronchial epithelial cells and type II pneumocytes (10) . While coronaviruses related to SARS-CoV-2 use ACE2 as a primary receptor, coronaviruses may use other proteases as receptors, such as CD26 (DPP4) for MERS-CoV (16) , thus limiting or extending their host range......
Document: The host range of SARS-CoV-2 may be extremely broad due to the conservation of ACE2 in mammals (2, 13) and its expression on ciliated bronchial epithelial cells and type II pneumocytes (10) . While coronaviruses related to SARS-CoV-2 use ACE2 as a primary receptor, coronaviruses may use other proteases as receptors, such as CD26 (DPP4) for MERS-CoV (16) , thus limiting or extending their host range.
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