Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_106
Snippet: Nsp11 is a small uncharacterized protein cleaved from the replicase polyprotein 1a. This small protein with unknown function requires experimental insights to further characterize this protein. The intrinsic disorder predicting software used in this study requires amino acid sequences, which are at least 30-residue long. Therefore, because of their short sequences (just 13 residues) Nsp11s from all three studied coronaviruses were not checked for.....
Document: Nsp11 is a small uncharacterized protein cleaved from the replicase polyprotein 1a. This small protein with unknown function requires experimental insights to further characterize this protein. The intrinsic disorder predicting software used in this study requires amino acid sequences, which are at least 30-residue long. Therefore, because of their short sequences (just 13 residues) Nsp11s from all three studied coronaviruses were not checked for the intrinsic disorder, disorder-based protein binding regions, and nucleotide-binding residues. Based on the MSA outputs, Nsp11 from SARS-CoV-2 was found to have a sequence identity of 84.62% with Nsp11s from Human SARS and Bat CoV (Figure 34 ).
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