Author: Weicheng Liang; Zhijie Feng; Shitao Rao; Cuicui Xiao; Zexiao Lin; Qi Zhang; Wei Qi
Title: Diarrhea may be underestimated: a missing link in 2019 novel coronavirus Document date: 2020_2_11
ID: bnv38la3_22
Snippet: Given that the distribution of ACE2 receptor may determine the route of 2019-nCoV infection and ACE2 is highly expressed in the small intestine, we next evaluated the expression profiles of ACE2 in different cell populations of the small intestine. Currently, single-cell RNA sequencing (scRNA-Seq) technology is a powerful tool that enables us to investigate the ACE2 expression in various cell types and provide quantitative information at single-c.....
Document: Given that the distribution of ACE2 receptor may determine the route of 2019-nCoV infection and ACE2 is highly expressed in the small intestine, we next evaluated the expression profiles of ACE2 in different cell populations of the small intestine. Currently, single-cell RNA sequencing (scRNA-Seq) technology is a powerful tool that enables us to investigate the ACE2 expression in various cell types and provide quantitative information at single-cell resolution. Based on the scRNA-Seq data (GSE92332) 12 , we utilized the bioinformatics tools to re-analyze the data. In total, we analyzed 7,216 individual cells derived from the small intestine of normal C57BL/6 mice. Using the unsupervised graph-based clustering, we found that the small intestine tissues consisted of at least eight distinct cell clusters according to their corresponding marker gene expression . CC-BY 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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