Selected article for: "analytical sensitivity and specificity sensitivity"
Author: Gustavo Barcelos Barra; Ticiane Henriques Santa Rita; Pedro Goes Mesquita; Rafael Henriques Jacomo; Lidia Freire Abdalla Nery
Title: Analytical sensibility and specificity of two RT-qPCR protocols for SARS-CoV-2 detection performed in an automated workflow
  • Document date: 2020_3_10
    • ID: kv77pw7y_1
    Snippet: On 30 January 2020, the World Health Organization declared that the COVID-19 outbreak constituted a Public Health Emergency of International Concern and the development of reliable laboratory diagnosis of SARS-CoV-2 became mandatory to identify, isolate and provide optimized care for patients early 1 . RT-qPCR testing of respiratory secretions is routinely used to detect causative viruses in acute respiratory infection and, during a Public Health.....
    Document: On 30 January 2020, the World Health Organization declared that the COVID-19 outbreak constituted a Public Health Emergency of International Concern and the development of reliable laboratory diagnosis of SARS-CoV-2 became mandatory to identify, isolate and provide optimized care for patients early 1 . RT-qPCR testing of respiratory secretions is routinely used to detect causative viruses in acute respiratory infection and, during a Public Health Emergency of International Concern, the establishment of standardized processes and protocols, as well as sharing of specimens, data, and information is critical. RT-qPCR in-house protocols to detect the SARS-CoV-2 have been described 2 . Validations of these protocols are considered a key knowledge gap for COVID-19, especially if executed in a high throughput format. Here, we investigate the analytical sensitivity and specificity of two interim RT-qPCR protocols 3,4 for the qualitative detection of SARS-CoV-2 executed in a fully automated platform.

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