Author: William E. Diehl; Mehmet H. Guney; Pyae Phyo Kyawe; Judith M. White; Massimo Pizzato; Jeremy Luban
Title: Influence of different glycoproteins and of the virion core on SERINC5 antiviral activity Document date: 2019_9_24
ID: 9dybtdi2_4
Snippet: HIV-1 is not the only virus inhibited by SERINC5. SIVs lacking nef are also inhibited by SERINC5 and SIV nefs counteract this inhibition (17) with a potency that is proportional to the prevalence of SIV in wild primate populations (21) . Two examples of convergent evolution of anti-SERINC function by virally encoded proteins are found outside of primate immunodeficiency viruses. Murine leukemia virus (MLV) Glycogag and equine infectious anemia vi.....
Document: HIV-1 is not the only virus inhibited by SERINC5. SIVs lacking nef are also inhibited by SERINC5 and SIV nefs counteract this inhibition (17) with a potency that is proportional to the prevalence of SIV in wild primate populations (21) . Two examples of convergent evolution of anti-SERINC function by virally encoded proteins are found outside of primate immunodeficiency viruses. Murine leukemia virus (MLV) Glycogag and equine infectious anemia virus (EIAV) S2 are viral antagonists of SERINC5 activity, and neither share sequence or structural homology with Nef, nor to each other (17, (22) (23) (24) .
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