Author: Kaifu Gao; Duc Duy Nguyen; Rui Wang; Guo-Wei Wei
Title: Machine intelligence design of 2019-nCoV drugs Document date: 2020_2_4
ID: 1qniriu0_2
Snippet: The spike protein (S-protein), which is known as the multi-functional molecular machine that mediates coronavirus entry into host cells 9 is discussed to answer the question mentioned above. According to the literature, 5, 6 the 2019-nCoV and the SARS-CoV have a high amino acid sequence homology of the S-protein, which can result in severe human infections. Further structural similarity analysis showed and confirmed that the S-protein of 2019-nCo.....
Document: The spike protein (S-protein), which is known as the multi-functional molecular machine that mediates coronavirus entry into host cells 9 is discussed to answer the question mentioned above. According to the literature, 5, 6 the 2019-nCoV and the SARS-CoV have a high amino acid sequence homology of the S-protein, which can result in severe human infections. Further structural similarity analysis showed and confirmed that the S-protein of 2019-nCoV uses the same human cell receptor angiotensin-converting enzyme 2 (ACE2) as SARS-CoV. 4, 10 Therefore, similar approaches can be applied to prevent the S-protein binding with the receptor ACE2.
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