Author: Yafei Wang; Randy Heiland; Morgan Craig; Courtney L. Davis; Ashlee N Ford Versypt; Adrianne Jenner; Jonathan Ozik; Nicholson Collier; Chase Cockrell; Andrew Becker; Gary An; James A. Glazier; Aarthi Narayanan; Amber M Smith; Paul Macklin
Title: Rapid community-driven development of a SARS-CoV-2 tissue simulator Document date: 2020_4_5
ID: lq4tcyh4_135
Snippet: Note that virus propagation may require more explicit modeling of cell-cell surface contact in later versions, as well as cilia-driven advective transport and virion deposition (e.g., through airway transport). Within each cell, we track V (adhered virions in the process of endocytosis), U (uncoated viral RNA and proteins), R (viral RNA ready for protein synthesis; R = 1 denotes one virion's total mRNA), P (synthesized viral proteins; P = 1 denot.....
Document: Note that virus propagation may require more explicit modeling of cell-cell surface contact in later versions, as well as cilia-driven advective transport and virion deposition (e.g., through airway transport). Within each cell, we track V (adhered virions in the process of endocytosis), U (uncoated viral RNA and proteins), R (viral RNA ready for protein synthesis; R = 1 denotes one virion's total mRNA), P (synthesized viral proteins; P = 1 denotes sufficient viral protein to assemble a complete virion), and A (total assembled virions ready for exocytosis). Virion import (a source term for V) is handled automatically by the mass conservation terms for PhysiCell in the PDE solutions.
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