Author: Wei Lin; Longfei Hu; Yan Zhang; Joshua D. Ooi; Ting Meng; Peng Jin; Xiang Ding; Longkai Peng; Lei Song; Zhou Xiao; Xiang Ao; Xiangcheng Xiao; Qiaoling Zhou; Ping Xiao; Jue Fan; Yong Zhong
Title: Single-cell Analysis of ACE2 Expression in Human Kidneys and Bladders Reveals a Potential Route of 2019-nCoV Infection Document date: 2020_2_18
ID: mm2sp48e_2
Snippet: Based on bioinformatics analyses, it has been shown that 2019-nCoV genome is 88% identical with two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses (bat-SL-CoVZC45 and bat-SL-CoVZXC21), 79% with SARS-CoV, and 50% with MERS- Single-cell RNA sequencing (scRNA-Seq) has been extensively applied in 2019-nCoV research, due to its capability to profile gene expressions for all cell types in multiple tissues unbiasedly at a high r.....
Document: Based on bioinformatics analyses, it has been shown that 2019-nCoV genome is 88% identical with two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses (bat-SL-CoVZC45 and bat-SL-CoVZXC21), 79% with SARS-CoV, and 50% with MERS- Single-cell RNA sequencing (scRNA-Seq) has been extensively applied in 2019-nCoV research, due to its capability to profile gene expressions for all cell types in multiple tissues unbiasedly at a high resolution. In addition to well-known alveolar type 2 cells in lung, expression of ACE2 has also been investigated in liver cholangiocytes, esophagus epithelial cells and absorptive enterocytes of ileum and colon by scRNA-Seq [11] [12] [13] . These results demonstrated the potential utility of scRNA-Seq to unmask the potential target cell types of 2019-nCoV. Since the urinary system infection and its potential aftermath could be essential to the patient care during and after the infection, here we used two scRNA-Seq transcriptome data in healthy kidneys and one dataset in heathy bladders to investigate the expression patterns of cell types in the urinary system.
Search related documents:
Co phrase search for related documents- absorptive enterocyte and gene expression: 1
- acute respiratory syndrome and alveolar type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and bioinformatic analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- acute respiratory syndrome and cell type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and cell type gene expression: 1
- acute respiratory syndrome and colon ileum: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory syndrome and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and expression pattern: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and healthy kidney: 1, 2
- alveolar type and cell type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- alveolar type and cell type gene expression: 1, 2, 3
- alveolar type and colon ileum: 1
- alveolar type and epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- alveolar type and expression pattern: 1, 2, 3
- alveolar type and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- bioinformatic analysis and epithelial cell: 1, 2, 3, 4, 5, 6
- bioinformatic analysis and expression pattern: 1, 2, 3
- bioinformatic analysis and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
Co phrase search for related documents, hyperlinks ordered by date