Author: Wodrich, Harald; Henaff, Daniel; Jammart, Baptist; Segura-Morales, Carolina; Seelmeir, Sigrid; Coux, Olivier; Ruzsics, Zsolt; Wiethoff, Christopher M.; Kremer, Eric J.
Title: A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry Document date: 2010_3_19
ID: 1mjmttec_40
Snippet: Here we present several lines of evidence that protein VI plays an additional and previously unidentified role in nuclear targeting of the Ad capsid. We show that protein VI exposure from Ad5 capsids occurs within minutes when pre-adsorbed Ad5 is shifted from 4uC to 37uC. This is consistent with the loss of the fiber prior to internalization and the rapid accumulation of Ad5 in the cytosol [41, 42] . We found that significant amounts of protein V.....
Document: Here we present several lines of evidence that protein VI plays an additional and previously unidentified role in nuclear targeting of the Ad capsid. We show that protein VI exposure from Ad5 capsids occurs within minutes when pre-adsorbed Ad5 is shifted from 4uC to 37uC. This is consistent with the loss of the fiber prior to internalization and the rapid accumulation of Ad5 in the cytosol [41, 42] . We found that significant amounts of protein VI remains partially associated with the viral capsid after the initial exposure and until the viral particle accumulates at the MTOC or the nuclear rim.
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