Author: Shehata, Mahmoud M.; Kandeil, Ahmed; Mostafa, Ahmed; Mahmoud, Sara H.; Gomaa, Mokhtar R.; El-Shesheny, Rabeh; Webby, Richard; Kayali, Ghazi; A. Ali, Mohamed
Title: A Recombinant Influenza A/H1N1 Carrying A Short Immunogenic Peptide of MERS-CoV as Bivalent Vaccine in BALB/c Mice Document date: 2019_12_2
ID: 15q6qr4z_4
Snippet: Due to the well-studied safety profile of IAVs and their easy propagation and production using either embryonated chicken eggs or cell culture systems, several studies have used recombinant IAVs to either express certain immune modulators and anticancer proteins to combat cancer cells (oncolytic virus) [13, 14] . Yang et al. (2014) , synthesized short peptide 25 amino acid (aa) residues from spike protein of MERS-CoV at position 736-761 (CALPDTPS.....
Document: Due to the well-studied safety profile of IAVs and their easy propagation and production using either embryonated chicken eggs or cell culture systems, several studies have used recombinant IAVs to either express certain immune modulators and anticancer proteins to combat cancer cells (oncolytic virus) [13, 14] . Yang et al. (2014) , synthesized short peptide 25 amino acid (aa) residues from spike protein of MERS-CoV at position 736-761 (CALPDTPSTLTPRSVRSVPGEMRLA), which elicited nAbs in mice and rabbits against MERS-CoV [15] . Herein, we used a recombinant influenza A H1N1pdm09pandemic (A/California/04/2009) as a PR8-based vector to express an immunogenic short peptide residue of the spike protein of MERS-CoV elicited immunity against MERS-CoV and H1N1pdm09. This short peptide was inserted in the neuraminidase gene of A/California/04/2009 (H1N1) for production of a PR8-based bivalent vaccine against influenza and MERS-CoV.
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